Therapeutic Potential of Chemically Modified miR-489 in Triple-Negative Breast Cancers
نویسندگان
چکیده
منابع مشابه
Revealing targeted therapeutic opportunities in triple-negative breast cancers
*Correspondence to: Powel H Brown, Email: [email protected] Submitted: 06/20/13; Accepted: 06/24/13 http://dx.doi.org/10.4161/cc.25871 Comment on: Hartman ZC, et al. Cancer Res 2013; 73:3470-80; PMID:23633491; http://dx.doi.org/10.1158/0008-5472.CAN-12-4524-T Breast cancer is second only to nonmelanoma skin cancers as the most prevalent and lethal malignancy among women worldwide. Upon dia...
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Triple negative breast cancers (TNBCs) account for 15% of all breast cancers, and represent one of the most aggressive forms of the disease, exhibiting short relapse-free survival. In contrast to other breast cancer subtypes, the absence of knowledge about the etiopathogenic alterations that cause TNBCs force the use of chemotherapeutics to treat these tumors. Because of this, efforts have been...
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Research focused on the analysis and classification of breast tumors, primarily using DNA microarrays and patterns of gene expression, has resulted in distinct tumor subtypes. Although no knowledge of patient survival or outcomes was used to derive these gene descriptions, these different classes based upon patterns of gene expression have important prognostic implications. Predictive markers i...
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The term triple-negative breast cancer (TNBC) defines breast tumors that do not express estrogen receptors, progesterone receptor or epidermal growth factor receptor HER2 on immunohistochemical analysis. TNBC accounts for 12-17% of all types of breast cancer. Molecular profiling indicated that triple-negative breast cancer represents a heterogeneous subgroup of breast cancer. Triple-negative br...
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ژورنال
عنوان ژورنال: Cancers
سال: 2020
ISSN: 2072-6694
DOI: 10.3390/cancers12082209